198419-91-9
基本信息
化合物 LY367385 HYDROCHLORIDE
LY-367385 hydrochloride
SGIKDIUCJAUSRD-QMMMGPOBSA-N
(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid
Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-
(R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid
(S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
LY-367385
(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
物理化学性质
| 储存条件 | Desiccate at RT |
| 溶解度 | H2O：>10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至灰白色 |
安全数据
| WGK Germany | 3 |
LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY367385 hydrochloride | 198419-91-9 | 5mg | 850元 |
| 2024/04/30 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY367385 hydrochloride | 198419-91-9 | 10mM * 1mLin DMSO | 940元 |
| 2024/04/30 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY367385 hydrochloride | 198419-91-9 | 10mg | 1450元 |
常见问题列表
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mGluR1a 8.8 μM (IC 50 ) |
LY367385 combined with N-methyl-D-aspartate (NMDA) during the toxic pulse attenuates neuronal degeneration in a concentration-dependent fashion, with a maximal reduction of NMDA toxicity ranging from 40 to 60%. LY367385 shows greater efficacy than LY367366 and neither of these compounds influenced neuronal viability per se. LY367385 shows potent neuroprotective effects, with causing a 50% reduction in (S)-3,5-Dihydroxyphenylglycine (DHPG) potentiation at a concentration of 10 nM. Under experimental conditions at higher concentrations of antagonist, LY367385 a completely antagonized the amplification of NMDA toxicity by DHPG.
LY367385 has been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice, LY367385 produces a rapid, transient suppression of sound-induced clonic seizures ED50 = 12 nM, i.c.v., 5 min). In lethargic mice, LY367385 significantly reduces the incidence of spontaneous spike and wave discharges on the electroencephalogram, from 30 to >150 min after the administration of LY367385, 250 nM, i.c.v.
In genetically epilepsy prone rats, LY367385 reduces sound-induced clonic seizures. LY367385, 160 nM bilaterally, fully suppresses clonic seizures after 2-4 h.