169869-90-3
基本信息
甲磺酸伊喜替康
依沙替康甲磺酸盐
依喜替康甲磺酸盐
(1S,9S)-1-氨基-9-乙基-5-氟-9-羟基-4-甲基-2,3,9,10,13,15-六氢-1H,12H-苯并[DE]吡喃[3',4':6,7]氮茚并[1,2-B]喹啉-10,13-二酮甲磺酸盐
Exatecan Meslate
Exatecan mesilate
169869-90-3 （free base）
Exatecan?Mesylate top3
DX8951F
DX 8951F
DX-8951F
Exatecan Mesylate (DX8951f)
Exatecan (DX-8951) mesylate
DX 8951
DX 8951
169869-90-3 (FREE BASE)
(1S,9S)-1-AMINO-9-ETHYL-5-FLUORO-9-HYDROXY-4-METHYL-2,3,9,10,13,15-HEXAHYDRO-1H,12H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE MESYLATE
物理化学性质
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| 溶解度 | DMSO:7.41(Max Conc. mg/mL);13.94(Max Conc. mM) Water:0.0(Max Conc. mg/mL);0.19(Max Conc. mM) |
| 形态 | 固体 |
| 颜色 | Light yellow to green yellow |
| 稳定性 | 吸湿性 |
| InChIKey | BICYDYDJHSBMFS-OVCYJQQENA-N |
| SMILES | S(O)(=O)(=O)C.N[C@H]1CCC2C(C)=C(F)C=C3N=C4C5=CC6[C@@](C(=O)OCC=6C(=O)N5CC4=C1C3=2)(O)CC |&1:6,21,r| |
安全数据
| 危险性符号(GHS) |   GHS06,GHS07 |
| 警示词 | 危险 |
| 危险性描述 | H301-H315-H319-H335 |
| 防范说明 | P261-P264-P270-P271-P280-P301+P310-P321-P330-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 |
| WGK Germany | WGK 3 |
| 存储类别 | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| 危险性类别 | Acute Tox. 2 Oral Muta. 1B Repr. 1B |
常见问题列表
甲磺酸伊喜替康是一种DNA 拓扑异构酶 I (topoisomerase I) 抑制剂，IC50 值为 2.2 μM (0.975 μg/mL)，可用于癌症研究。
|
Topoisomerase I 0.975 μg/mL (IC 50 ) |
Exatecan mesylate is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.
Exatecan mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.
甲磺酸伊喜替康价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-13631A | 甲磺酸伊喜替康 Exatecan mesylate | 169869-90-3 | 5 mg | 125元 |
| 2026/09/15 | HY-13631A | 甲磺酸伊喜替康 Exatecan mesylate | 169869-90-3 | 10 mM * 1 mLin DMSO | 146元 |
| 2026/09/15 | HY-13631A | 甲磺酸伊喜替康 Exatecan mesylate | 169869-90-3 | 10 mg | 200元 |