1630203-25-6
英文名称
Benzamide, 3-[[4-[[4-[[[[5-(1,1-dimethylethyl)-2-methoxy-3-[(methylsulfonyl)amino]phenyl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]amino]-5-methoxy-N-[3-(4-morpholinyl)propyl]-
CAS
1630203-25-6
分子式
C43H51N7O8S
分子量
825.97
MOL 文件
1630203-25-6.mol
结构式
基本信息
英文别名
TOP1362
Benzamide, 3-[[4-[[4-[[[[5-(1,1-dimethylethyl)-2-methoxy-3-[(methylsulfonyl)amino]phenyl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]amino]-5-methoxy-N-[3-(4-morpholinyl)propyl]-
Benzamide, 3-[[4-[[4-[[[[5-(1,1-dimethylethyl)-2-methoxy-3-[(methylsulfonyl)amino]phenyl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]amino]-5-methoxy-N-[3-(4-morpholinyl)propyl]-
应用领域
用途一
TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.