1544739-76-5
中文名称
化合物 MK-8666
英文名称
Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-
CAS
1544739-76-5
分子式
C29H31NO6S
分子量
521.62
MOL 文件
1544739-76-5.mol
结构式
基本信息
中文别名
化合物 MK-8666
英文别名
Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-
物理化学性质
| 沸点 | 741.8±60.0 °C(Predicted) |
| 密度 | 1.304±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.94±0.20(Predicted) |
应用领域
用途一
MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.