基本信息 物理化学性质 常见问题列表 供应商 相关产品
网站主页Cas数据库列表154447-38-8

154447-38-8

中文名称 8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名称 LY 303511
CAS 154447-38-8
分子式 C19H18N2O2
分子量 306.36
MOL 文件 154447-38-8.mol
更新日期 2024/06/20 21:07:17
结构式 154447-38-8 结构式

基本信息

中文别名 8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文别名 LY303511, >=98%
LY-303511(Nv-128)
LY 303511
LY303511
8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one
2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-
8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one LY303511

物理化学性质

沸点 496.1±45.0 °C(Predicted)
密度 1.237±0.06 g/cm3(Predicted)
储存条件 Store at +4°C
溶解度 Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
酸度系数(pKa) 9.20±0.10(Predicted)
形态 琥珀色固体

常见问题列表

生物活性
LY303511 是 LY294002 的一种结构类似物,但 LY303511 不抑制 PI3K。LY303511 可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性。LY303511 可逆地阻断 MIN6 胰岛瘤细胞中的 K+ 电流 (IC50=64.6±9.1 μM)。
靶点

TRAIL
IC50: 64.6±9.1 µM (K + currents, in MIN6 insulinoma cells)

体外研究

LY303511 is structurally identical to LY294002 except for a substitution of -O for -NH in the morpholine ring, and does not potently inhibit PI3K. Treatment of cells with LY303511 causes an increase in calcein spread similar to levels of LY294002. The ability of LY303511 to increase gap junctional intercellular communication (GJIC) does not occur concomitant with inhibition of phosphorylation of AKT as measured by immunoblotting. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via H 2 O 2 -MAPK activation and up-regulation of death receptors. SHEP-1 cells are exposed to varying concentrations of LY303511 (LY30), TRAIL, and a combination of the two (1 h preincubation with LY303511 followed by TRAIL for 4 hours). SHEP-1 cells are responsive to TRAIL (~10%, ~15%, and ~30% reduction in the surviving fraction at 25, 50, and 100 ng/mL, respectively); however, treatment with LY303511 (12.5, 25, or 50 μM) has no effect on cell viability. However, incubation of cells with LY303511 (25 μM) for 1 hour followed by 4 hours exposure to 50 ng/mL of TRAIL has a strong synergistic effect (~40% reduction in viable cells with LY303511+TRAIL versus ~15% with TRAIL alone). LY303511 is a negative control compound with respect to PI3K activity. In MIN6 insulinoma cells, Wortmannin (100 nM) has no effect on whole-cell outward K + currents, but LY294002 and LY303511 reversibly block currents in a dose-dependent manner (IC 50 =9.0±0.7 μM and 64.6±9.1 μM, respectively). Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 μM LY294002 and 100 μM LY303511 reversibly inhibit currents by 99% and 41%, respectively. LY303511 blocks currents with an IC 50 of 64.6±9.1 µM, with a maximal inhibition of ~90% at 500 µM (n≥5 cells at each concentration).

体内研究

Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm 3 , at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo.

供应商信息 更多

武汉易泰科技有限公司上海分公司
联系电话: 821-50328103-801 18930552037
产品介绍:
英文名称:LY 303511;2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS:154447-38-8
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海楼岚生物科技有限公司
联系电话: 021-52996696,15000506266 15000506266
产品介绍:
英文名称:LY303511
CAS:154447-38-8
上海一飞生物科技有限公司
联系电话: 021-65675885 18964387627
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:95%
包装信息:1mg;5mg;10mg
备注:试剂级
上海瀚香生物科技有限公司
联系电话: 177-54423994 17754423994
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:98% HPLC LCMS
包装信息:100mg;500mg;1g;5g;10g
备注:量大优惠,现货促销
上海巢莱化工科技中心
联系电话: 021-2022843681 15618226720
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:95%
包装信息:1G,5G,10G,50G,100G,1KG
北京普西唐生物科技有限公司
联系电话: 010-60605840 18892239720
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:98%
包装信息:5mg;10mg;50mg;100mg
滁州市科迈尔化工科技有限公司
联系电话: 0550-5196001 15000891977
产品介绍:
CAS:154447-38-8
西安莱茵生物科技有限公司
联系电话: 86-(0)29-85992781 17792393971
产品介绍:
中文名称:8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名称:LY 303511
CAS:154447-38-8
纯度:95%
包装信息:1mg;5mg
苏州爱玛特生物科技有限公司
联系电话: 0512-56316828
产品介绍:
英文名称:LY303511
CAS:154447-38-8
纯度:97% HPLC
包装信息:5g;25g;100g;1kg
上海凯裕医药科技有限公司
联系电话: 17317130613
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:98% HPLC
包装信息:1G;5G
成都圣美凯生物科技有限公司
联系电话: 028-85157043 15882256948
产品介绍:
英文名称:LY-303511
CAS:154447-38-8
纯度:95%
上海源溪生物科技有限公司
联系电话: 021-58447131 13564518121
产品介绍:
中文名称:8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名称:LY-303511(Nv-128)
CAS:154447-38-8
纯度:98% HPLC
包装信息:100mg,250mg,1g
备注:仅供科研所需
常州辰鸿生物科技有限公司
联系电话: 0519-85788828 13775037613
产品介绍:
英文名称:LY303511
CAS:154447-38-8
纯度:99%
包装信息:50mg;100mg;250mg;500mg;1g;5g
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
爱必信(上海)生物科技有限公司
联系电话: 021-38015121 15000105423
产品介绍:
英文名称:LY 303511
CAS:154447-38-8
纯度:98%
包装信息:5mg;10mg;25mg;50mg
学研惠(武汉)科技有限公司
联系电话: 15342225168
产品介绍:
中文名称:8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名称:LY 303511
CAS:154447-38-8
纯度:97%~99% HPLC
包装信息:1mg;1g;10g;100g;1Kg;10Kg;100Kg;1T
安耐吉化学&3A(安徽泽升科技有限公司)
联系电话: 021-58432009 400-005-6266
产品介绍:
英文名称:LY303511
CAS:154447-38-8
纯度:NULL
包装信息:1mg;2.5mg
备注:NULL
MedBio脉铂医药
联系电话: 021-69568360 18916172912
产品介绍:
中文名称:8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮
英文名称:LY 303511
CAS:154447-38-8
纯度:98%
包装信息:50mg; 5mg; 10mg
备注:Medbio

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