153192-22-4
中文名称
YM 15430-1
英文名称
YM 15430-1
CAS
153192-22-4
分子式
C29H35N3O8
分子量
553.6
MOL 文件
153192-22-4.mol
结构式
物理化学性质
| 沸点 | 729.3±60.0 °C(Predicted) |
| 密度 | 1.240±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.98±0.20(Predicted) |
应用领域
用途一
YM-430, also known as YM-15430; YM-154301; is a dual of β1 adrenergic receptor antagonist and calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent, because of its dual activities. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO. YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina.