144335-37-5
中文名称
化合物 FGF/PDGF/VEGF RTK INHIBITOR
英文名称
3-(1H-benzo[d]imidazol-2-yl)quinoline-2,4-diol
CAS
144335-37-5
分子式
C16H11N3O2
分子量
277.28
MOL 文件
144335-37-5.mol
结构式
物理化学性质
| 密度 | 1.499±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: 5mg/mL |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
| 形态 | solid |
| 颜色 | off-white |
| InChI | 1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21) |
| InChIKey | YXCWBNCDJZEBKY-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(nc1c3c(nc4c(c3O)cccc4)O)cccc2 |
应用领域
用途一
FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm).
安全数据
| WGK Germany | WGK 2 |
| 存储类别 | 11 - Combustible Solids |