142999-59-5
中文名称
化合物 T32033
英文名称
GYKI 46903
CAS
142999-59-5
分子式
C17H21ClFNO2
分子量
325.81
MOL 文件
142999-59-5.mol
结构式
应用领域
用途一
GYKI-46903 is a non-competitive antagonist for 5-HT3 receptors. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. GYKI-46903, when administered by intravenous infusion, antagonized the decrease in heart rate evoked by serotonin (Bezold-Jarisch reflex) in anaesthetized rats, and the maximal reversal was less than 50%.