133575-27-6
CAS
133575-27-6
结构式
常见问题列表
生物活性
Ara-F-NAD+ 是 NAD+ 的 arabino 类似物，是一种有效的、缓慢结合的 CD38 NADase 抑制剂，其 Ki 为 1. 69 nM.
体外研究
The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD + glycohydrolase that transforms NAD + into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity).