13095-47-1
基本信息
D-2-hydroxyglutarate
D--Hydroxyglutaric Acid
D-α-Hydroxyglutaric Acid
D-2-Hydroxyglutaric acid
(2R)-hydroxyglutaric acid
(R)-2-Hydroxyglutaric acid
2-hydroxypentanedioic acid
D-alpha-Hydroxyglutaric acid
(R)-alpha-Hydroxyglutaric acid
物理化学性质
| 沸点 | 394.2±27.0 °C(Predicted) |
| 密度 | 1.508±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; PBS (pH 7.2): 10 mg/mL |
| 酸度系数(pKa) | 3.67±0.10(Predicted) |
R-2-羟基戊二酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/03/20 | HY-113038 | R-2-羟基戊二酸 D-α-Hydroxyglutaric acid | 13095-47-1 | 5mg | 1800元 |
| 2023/03/20 | HY-113038 | R-2-羟基戊二酸 D-α-Hydroxyglutaric acid | 13095-47-1 | 10mg | 2900元 |
| 2023/03/20 | HY-113038 | R-2-羟基戊二酸 D-α-Hydroxyglutaric acid | 13095-47-1 | 25mg | 4400元 |
常见问题列表
Ki: 10.87 mM (α-KG-dependent dioxygenases)
ATP synthase
mTOR
Reactive oxygen species (ROS)
D-α-Hydroxyglutaric acid ((R)-2-hydroxyglutarate) accumulates in human cancers carrying neomorphic mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes.
A partial inhibition of KDM7A toward both H3K9me2 and H3K27me2 peptides is observed in the presence of 50 mM D-2-HG and 100 μM α-ketoglutarate (α-KG). Addition of 300 μM α-KG is capable of reversing the inhibition of
Caenorhabditis elegans
KDM7A (CeKDM7A) by 50 mM D-2-HG, indicating that D-2-HG is a weak competitive inhibitor against α-KG toward the CeKDM7A demethylase.
D-α-Hydroxyglutaric acid is a weak inhibitor of TET hydroxylases. In the presence of 0.1 mM of α-KG, addition of 10 mM D-α-Hydroxyglutaric acid results in a partial (33%) inhibition of TET2 and addition of 50 mM D-α-Hydroxyglutaric acid results in more inhibition (83%) of TET2. D-α-Hydroxyglutaric acid exhibits a less pronounced inhibitory effect toward TET1.
D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO
2
production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.