125598-87-0
中文名称
化合物 T26482
英文名称
A 57696
CAS
125598-87-0
分子式
C35H47N7O8
分子量
693.8
MOL 文件
125598-87-0.mol
结构式
物理化学性质
| 沸点 | 1081.5±65.0 °C(Predicted) |
| 密度 | 1.272±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.20±0.10(Predicted) |
应用领域
用途一
A-57696 is a cholecystokinin antagonist. It is selective for cortical CCK-B receptors (IC50 = 25 nM), compared with pancreatic CCK-A receptors (IC50 = 15 microM). It is a competitive antagonist in reversing CCK8-stimulated pancreatic amylase secretion and phosphoinositide breakdown. A-57696 behaved as a partial agonist in stimulating calcium mobilization at CCK-B/gastrin receptors.