1222088-90-5
中文名称
AM 5262
英文名称
AM 5262
CAS
1222088-90-5
分子式
C33H35FO4
分子量
514.63
MOL 文件
1222088-90-5.mol
结构式
物理化学性质
| 沸点 | 657.7±55.0 °C(Predicted) |
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.71±0.20(Predicted) |
应用领域
用途一
AM-5262 is a Potent GPR40 Full Agonist with improved rat PK profile and general selectivity profile. AM-5262 enhanced glucose stimulated insulin secretion (mouse and human islets) and improved glucose homeostasis in vivo (OGTT in HF/STZ mice) when compared to AM-1638. GPR40 (FFAR1 or FFA1) is a target of high interest being pursued to treat type II diabetes due to its unique mechanism leading to little risk of hypoglycemia.
常见问题列表
概述
AM-5262 是一种 GPR40 完全激动剂，EC50 值为 0.081 μM。 AM-5262 可用于 II 型糖尿病的研究。