1214994-13-4

AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. It acts by significantly restoring decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively.

(S)-AS1069562 是 AS1069562 (HY-138257A) 的 S 型异构体。AS1069562 是具有口服活性的 5-HT 和 NE 再摄取抑制剂，IC50 值分别为 0.35 μM 和 3.3 μM。AS1069562 具有镇痛活性。AS1069562 可通过改善神经营养支持来改善神经功能损伤。