1207440-88-7
中文名称
化合物 T26569
英文名称
Acetamide, N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]-4,5-dihydro-6-methoxy-3,5-dioxo-1,2,4-triazin-2(3H)-yl]-2-fluorophenyl]-
CAS
1207440-88-7
分子式
C19H15ClF2N4O4
分子量
436.8
MOL 文件
1207440-88-7.mol
结构式
基本信息
中文别名
化合物 T26569
英文别名
Acetamide, N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]-4,5-dihydro-6-methoxy-3,5-dioxo-1,2,4-triazin-2(3H)-yl]-2-fluorophenyl]-
物理化学性质
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.65±0.70(Predicted) |
应用领域
用途一
ADX71441 is a GABAB positive allosteric modulator (PAM). ADX71441 increases urinary latencies and reduces the number of urinary events and the total and average urinary volumes. ADX71441 completely inhibits the micturition reflex and induced overflow incontinence in five out of 10 animals. GABAB PAM has potential as a novel approach for the treatment of overactive bladder. It may also mitigate alcoholism and have analgesic effects in the bladder.
常见问题列表
概述
ADX71441 是一种有效的、选择性的 GABAB 受体正变构调节剂。ADX71441 口服给药后具有生物利用度，并且具有脑渗透性。ADX71441 具有研究焦虑、疼痛和痉挛的潜力。