115039-00-4
CAS
115039-00-4
MOL 文件
115039-00-4.mol
结构式
常见问题列表
生物活性
AhR modulator-1 (compound 6-MCDF) 是一种选择性的口服活性芳烃受体 (AhR) 调节剂。AhR modulator-1 部分地通过在肿瘤形成之前抑制前列腺 VEGF 的产生而抑制肿瘤转移。AhR modulator-1 在大鼠子宫中也具有抗雌激素特性。
靶点
Aryl hydrocarbon receptor (AhR)
Prostatic VEGF
Estrogenic
体外研究
AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively.
Cell Proliferation Assay
| Cell Line: | ASPC-1 cells |
| Concentration: | 0.1 μM, 1 μM and 10 μM |
| Incubation Time: | 48 hours, 72 hours, 96 hours |
| Result: | Exhibited dose-dependent growth inhibitory effects. |
体内研究
AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced.
| Animal Model: | C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old) |
| Dosage: | 0 mg/kg, 10 mg/kg, 40 mg/kg |
| Administration: | Oral administration; daily; for 12 weeks |
| Result: | The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced. |
供应商信息 更多
天津普西唐生物医药科技有限公司
联系电话：
010-60605840 15801484223
产品介绍：
英文名称：AhR modulator-1
CAS：115039-00-4
包装信息：100mg;250mg;1g
备注： 试剂级
浙江虹舞科技有限公司
联系电话：
18255593606; 18255593606
产品介绍：
英文名称：6-methyl-1,3,8-trichlorodibenzofuran
CAS：115039-00-4
纯度：99% HPLC
包装信息：1kg;10kg;100kg
TargetMol中国（陶术生物）
联系电话：
15002134094
产品介绍：
中文名称：化合物 AhR modulator-1
英文名称：AhR modulator-1
CAS：115039-00-4
包装信息：50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500