1134188-71-8

Oxcarbazepine-d₄ is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine . It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED₅₀s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; ) or picrotoxin in rodents (ED₅₀s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.

奥卡西平-D4 是 Oxcarbazepine 氘代物。Oxcarbazepine 是一种钠通道 (sodium channel) 阻滞剂。Oxcarbazepine 有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡 (apoptosis) 或 G2/M 停滞。具有抗癌和抗惊厥作用。