111374-21-1
基本信息
2-Pyrazinecarboxamide, 6-(1-pyrrolidinyl)-N-2H-tetrazol-5-yl-
N-(1H-Tetrazol-5-yl)-6-(1-pyrrolidinyl)pyrazine-2-carboxamide
6-(1-Pyrrolidinyl)-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide
物理化学性质
| 熔点 | 288-294 °C (decomp)(Solv: dimethyl sulfoxide (67-68-5)) |
| 密度 | 1.555±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 2.61±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | Light yellow to yellow |
111374-21-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-U00133 | 111374-21-1 HSR6071 | 111374-21-1 | 1mg | 1590元 |
| 2024/11/08 | HY-U00133 | 111374-21-1 HSR6071 | 111374-21-1 | 5mg | 3500元 |
| 2024/11/08 | HY-U00133 | 111374-21-1 HSR6071 | 111374-21-1 | 10mg | 5600元 |
常见问题列表
The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea.
HSR-6071 inhibits the IgE-mediated histamine release with an IC
50
of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.