105226-30-0

Fluparoxan, also known as GR-50360; GR-50360A, is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). It was shown to possess central α2-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies.

Fluparoxan hydrochloride 是一种具有口服活性、选择性和竞争性的 α2-肾上腺素受体拮抗剂。Fluparoxan hydrochloride 是一种抗抑郁剂。