104195-17-7
中文名称
SDZ NVI-085
英文名称
SDZ NVI-085
CAS
104195-17-7
分子式
C15H21NO2S
分子量
279.4
MOL 文件
104195-17-7.mol
结构式
基本信息
中文别名
化合物 T28741
英文别名
SDZ NVI-085
naphtoxazine
[4aR,(-)]-3,4,4aβ,5,10,10aα-Hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine
naphtoxazine
[4aR,(-)]-3,4,4aβ,5,10,10aα-Hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine
应用领域
用途一
SDZ-NVI-085, also known as Naphtoxazine, is an α1 adrenergic receptor agonist potentially for the treatment of cognitive disorders and major depressive disorder. SDZ-NVI-085 behaves as a competitive antagonist of 5-hydroxytryptamine. SDZ-NVI-085 shifted 5-HT concentration-effect curves to the right, in a concentration-dependent manner, and Schild regression gave a pA2 estimate of 8.0.