1032265-67-0
中文名称
SIM 010603; SIM-010603
英文名称
SIM010603
CAS
1032265-67-0
分子式
C22H25FN4O2
分子量
396.46
MOL 文件
1032265-67-0.mol
结构式
物理化学性质
| 沸点 | 602.7±55.0 °C(Predicted) |
| 密度 | 1.294±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 11.68±0.20(Predicted) |
应用领域
用途一
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
常见问题列表
概述
Tafetinib analogue 1是酪氨酸激酶受体抑制剂Tafetinib (SIM010603)的类似物。