101387-97-7
中文名称
101387-97-7
英文名称
5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
CAS
101387-97-7
分子式
C22H25N3O2S
分子量
395.52
MOL 文件
101387-97-7.mol
结构式
基本信息
中文别名
化合物 T19549
英文别名
Ro-18-5362
5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
Indeno[5,6-d]imidazol-6(1H)-one, 5,7-dihydro-2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-5,5,7,7-tetramethyl-
5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
Indeno[5,6-d]imidazol-6(1H)-one, 5,7-dihydro-2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-5,5,7,7-tetramethyl-
物理化学性质
沸点 | 593.4±60.0 °C(Predicted) |
密度 | 1.27±0.1 g/cm3(Predicted) |
储存条件 | -20°C储存 |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 10.28±0.60(Predicted) |
常见问题列表
生物活性
Ro18-5362 是一种活性较低的 Ro 18-5364 前体。即使在浓度高达 0.1 mM 下,Ro 18-5362 也不能显着影响 H++K+-ATPase 活性。
体外研究
Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H + +K + )-ATPase activity and associated proton translocation. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H + +K + )-ATPase, decreasing enzymatic activity with an apparent K i of 0.1 μM.