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5-S-Cysteinyldopamine is a sulfur ether metabolite of dopamine that can induce neurodegeneration by inducing widespread oxidative stress and protein aggregation, characterized by protein carbonylation and glutathione depletion, and upregulating the expression of α-Syn and ERp57 proteins. 5-S-Cysteinyldopamine can be used in the study of neurodegenerative diseases, such as Parkinson's disease[1][2].

ChEBI: 5-S-Cysteinyldopamine is a S-conjugate.

α-synuclein

[1] Rosengren E, et al. Detection of 5-S-cysteinyldopamine in human brain. J Neural Transm. 1985;63(3-4):247-53. DOI:10.1007/BF01252029
[2] Aureli C, et al. 5-S-cysteinyldopamine neurotoxicity: Influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease. J Neurosci Res. 2014 Mar;92(3):347-58. DOI:10.1002/jnr.23318