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Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney[1]. Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract[2].

[1] Nan Xu, et al. A new saikogenin from the roots of Bupleurum bicaule. Chin J Nat Med. 2014 Apr;12(4):305-8. DOI:10.1016/S1875-5364(14)60060-1
[2] Pei Yu, et al. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes. Xenobiotica. 2017 Jan;47(1):11-19. DOI:10.3109/00498254.2016.1163753