ChemicalBook CAS DataBase List 99-57-0

99-57-0

Name	2-Amino-4-nitrophenol
CAS	99-57-0
EINECS(EC#)	202-767-9
Molecular Formula	C6H6N2O3
MDL Number	MFCD00007695
Molecular Weight	154.12
MOL File	99-57-0.mol

Synonyms

2-AMINO-4-NITROPHENOL 2-HYDROXY-5-NITROANILINE 3-AMINO-4-HYDROXYNITROBENZENE 4-NAP 4-NITRO-2-AMINOPHENOL PARA NITRO 2-AMINO PHENOL P-NITRO-O-AMINOPHENOL p-Nitro-o-aminophenol 4-Nitro-2-aminophenol 1-amino-2-hydroxy-5-nitrobenzene 1-hydroxy-2-amino-4-nitrobenzene 2-amino-4-nitrofenol 2-amino-4-nitro-pheno 4-nitro-2-aminofenol 4-nitro-2-aminofenol(czech) amino-2nitro-4phenol c.i.76530 ci76530 nci-c55958 p-nitroaminofenol rodol42

Chemical Properties

Appearance	OCHRE CRYSTALLINE POWDER
Melting point	140-143 °C (lit.)
Boiling point	322.46°C (rough estimate)
density	1.3617 (estimate)
vapor pressure	0.005Pa at 25℃
refractive index	1.6890 (rough estimate)
Fp	100 °C
storage temp.	Refrigerator, Under Inert Atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	6.82±0.22(Predicted)
color	Dark Yellow to Brown
Water Solubility	slightly soluble
Detection Methods	HPLC
BRN	776533
Henry's Law Constant	4.5×10⁶ mol/(m³Pa) at 25℃, HSDB (2015)
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	2-Amino-4-nitrophenol (99-57-0)
InChI	1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
InChIKey	VLZVIIYRNMWPSN-UHFFFAOYSA-N
SMILES	Nc1cc(ccc1O)[N+]([O-])=O
LogP	1.26
CAS DataBase Reference	99-57-0(CAS DataBase Reference)
IARC	3 (Vol. 57) 1993
EPA Substance Registry System	99-57-0(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . R68:Possible risk of irreversible effects. R43:May cause sensitization by skin contact. R40:Limited evidence of a carcinogenic effect. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S36:Wear suitable protective clothing . less more
RIDADR	2811
WGK Germany	2
RTECS	SJ6300000
Hazard Note	Irritant
TSCA	Yes
REACH Registrations	Active
HS Code	29071990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Hazardous Substances Data	99-57-0(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description

Orange prisms or yellow powder. No odor.

Reactivity Profile

Oxidation of this chemical may occur in the presence of air and violent decomposition may occur if 2-AMINO-4-NITROPHENOL(99-57-0) is allowed to dry out completely at elevated temperatures. 2-AMINO-4-NITROPHENOL(99-57-0) is stable when stored protected from light and under nitrogen for two weeks at temperatures up to 140° F, and storage under nitrogen for up to 24 weeks at room temperature (77° F) should produce no loss of stability. This chemical is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. 2-AMINO-4-NITROPHENOL(99-57-0) is also incompatible with iron.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for this chemical are not available. 2-AMINO-4-NITROPHENOL is probably combustible.

Chemical Properties

OCHRE CRYSTALLINE POWDER

Uses

2-Amino-4-nitrophenol is used in preparing some mordant dyes and in some hair dyes.

Uses

An aromatic constituent found in hair dyes and other cosmetic products with very low levels of mutagenic activity.

Definition

ChEBI: 2-Amino-4-nitrophenol is a member of 4-nitrophenols.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 82, 1955
The Journal of Organic Chemistry, 45, p. 4992, 1980 DOI: 10.1021/jo01312a039

99-57-0

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Preparation Products

Hazard Information

General Description

Reactivity Profile

Air & Water Reactions

Fire Hazard

Chemical Properties

Uses

Uses

Definition

Synthesis Reference(s)

Flammability and Explosibility

Purification Methods

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information