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Bis-aminooxy-PEG4 is a homobifunctional crosslinking reagent with great water soolubility. Aminooxy (ONH2) group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond or a hydroxylamine linkage under reduction condition Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005