97852-72-7

Name	tibenelast
CAS	97852-72-7
Molecular Formula	C13H14O4S
MDL Number	MFCD00890221
Molecular Weight	266.31
MOL File	97852-72-7.mol

Synonyms

LY-186655 tibenelast 5,6-Diethoxybenzo[b]thiophene-2-carboxylic acid Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy-

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Chemical Properties

Boiling point	440.8±40.0 °C(Predicted)
density	1.289±0.06 g/cm3(Predicted)
pka	3.54±0.30(Predicted)

Hazard Information

Uses

Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2].

References

[1] Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. DOI:10.1016/0024-3205(90)90093-7
[2] Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DOI:10.1159/000139039

Supplier

Wuxi AppTec

Telephone022-59987777 13552403979

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Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Telephone400-0628126

Websitehttp://www.aobchem.com.cn/

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