957-66-4

Off-white needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the root of Lindera strychnifolia Vill. of the Lauraceae family, the root and trunk of Neolitsea aciculata Koidz. of Nanrenshan, the root of Neolitsea hiiranensis Liu et Liao, and the root hairs of Neolitsea villosa (Blume) Merr.

Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

ChEBI: Isolinderalactone is a member of benzofurans. It has a role as a metabolite.

VEGFR2; Bcl-2

[1] Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.?Cancer Lett. 2020;478:71-81. DOI:10.1016/j.canlet.2020.03.009
[2] Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model.?Cancer Lett. 2019;443:25-33. DOI:10.1016/j.canlet.2018.11.027