Description
This nonsystemic organophosphate not registered for
U.S. usage is used to control nematodes and soil
insects on bananas and other crops in several countries.
The U.S. EPA has granted tolerances for cadusafos
in imported bananas, where it provides excellent control
of the burrowing nematode, Radopholus similis (22).
Cadusafos reportedly possesses reduced risk for contaminating
groundwater and provided good control of the citrus
nematode, Tylenchulus semipenetrans (23). Cadusafos is
commercially available in granular and microencapsulated
formulations.
Uses
CADUSAFOS is used in the agriculture industry
Uses
Insecticide; nematocide.
Definition
ChEBI: Cadusafos is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nematicide and an agrochemical.
General Description
Cadusafos is a nematicide used in controlling nematodes, soil insects and cutworms in a variety of fruits and vegetables. Its mode of action involves the inhibition of acetylcholinesterase.
Metabolic pathway
There is little published information on the metabolism of cadusafos.
What has been published suggests that the main route of metabolism in
animals is via hydrolysis to give 1-methyl-1-propanethiol which is then
thiooxidised.
Metabolism
The
acute oral LD50 values for rats and mice are 37.1 and
71.4 mg/kg, respectively. Inhalation LC50 (4 h) for rats
is 0.026 mg/L air. NOEL (2 yr) for rats is 1 mg/kg diet
(0.05 mg/kg/d) and ADI is 0.3 μg/kg. In mammals, it is
readily metabolized and is eliminated in the urine and
feces. The major metabolic route is hydrolysis to give
1-methyl-1-propanothiol, followed by oxidation. The halflife
in soils is 11–55 d.
