95037-06-2

C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids.¹ It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC₅₀ value of 8.8 μM.²

Octadecanoyl-L-threo-sphingosine is an ester product.

Store at -20°C

1. Sarmientos, F., Schwarzmann, G., and Sandhoff, K. Direct evidence by carbon-13 NMR spectroscopy for the erythro configuration of the sphingoid moiety in Gaucher cerebroside and other natural sphingolipids Eur. J. Biochem. 146(1),59-64(1985).
2. Usta, J., El Bawab, S., Roddy, P., et al. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase Biochemistry 40(32),9657-9668(2001).