947669-91-2

WWL70 is a selective inhibitor of ABHD6.

In miceWWL70 guards against neuropathic pain stimulated by chronic constriction injury. It decreases the inflammatory response in the ipsilateral spinal corddorsal root ganglion (DRG) and sciatic nerve. WWL70 is considered as an anti-inflammatory therapeutic agentth at has the ability to prevent the synthesis of PGE2 (prostaglandin E2) and PGE2-G (PGE2-glyceryl ester).''WWL70 is a selective inhibitor of α/β-hydrolase domain-containing 6 (ABHD6)a serine hydrolase th at acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). It has an IC50 value of 55-70 nM and 90-95% inihibition of ABDH6. WWL70 hs been used in a variety of studies as an ABHD6 antagonist. It was shown to rescue impaired function of mGluR5 signalingresulting in pain inhibition in arthritic rats. WWL70 was also used to show th at ABHD6 is involved in brown adipose function and white adipose brown