94596-26-6

Name	dynorphin (1-11), Pro(10)-
CAS	94596-26-6
Molecular Formula	C63H103N21O13
Molecular Weight	1362.65
MOL File	94596-26-6.mol

Synonyms

<D-Pro10>dynorphin(1-11) dynorphin (1-11), Pro(10)- α-Neoendorphin (swine), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline- (9CI)

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Chemical Properties

density	1.42±0.1 g/cm3(Predicted)
pka	3.60±0.21(Predicted)
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys

Hazard Information

Uses

[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].

in vivo

[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially^[2].

References

[1] Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. DOI:10.1016/s0014-2999(97)81948-6
[2] Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. PMID:2898527

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