945762-00-5

nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1].

nNOS: 2.5 μM (IC₅₀); iNOS: 5.7 μM (IC₅₀); eNOS: 13 μM (IC₅₀)

[1] Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DOI:10.1016/j.bmc.2008.04.056