945170-74-1

Name	DS-22-inf-021
CAS	945170-74-1

Synonyms

DS-22-inf-021

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Hazard Information

Uses

DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses[1].

in vivo

DS-22-inf-021 (20-100 mg/kg, i.p., twice daily for 5 days and monitored for 14 days. ) increased survival rate in mice infected with IAV and IBV^[1].

Animal Model:	8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV^[1].
Dosage:	20, 50 and 100 mg/kg
Administration:	After 2 h post-infection, i.p. injection
Result:	Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg.

References

[1] Izmailyan R, et al. Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results. Antiviral Res. 2024 Feb;222:105818. DOI:10.1016/j.antiviral.2024.105818

Supplier

Shanghai Chaolan Chemical Technology Center

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Websitehttp://www.atkchemical.com/

Jinan Jiuli Biotechnology Co. , Ltd.

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Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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