Hazard Information
Uses
Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM[1].
in vivo
Figitumumab (CP-751871) (31-125 μg/mouse; i.p.; once) induces the down-regulation of tumor associated IGF-1R in mice[2].
Figitumumab (62.5-500 μg/mouse; i.p.; once) inhibits the growth of s.c. xenografts derived from colon (Colo-205), breast (MCF7), and lung (H460) cancer cell lines in mice[2].
| Animal Model: | Female athymic mice (CD-1 nu/nu) bearing NIH3T3/IGF-1R tumors[2] |
| Dosage: | 31 to 125 μg per mouse |
| Administration: | Intraperitoneal injection, once |
| Result: | Resulted in a serum Cmax between 12 and 24 hours. At 24 hours, there was a dose-dependent reduction of IGF-1R protein in tumors, with 50% reduction observed at a serum concentration of 15 μg/mL. Resulted in a down-regulation of IGF-1R from the tumor. The half-life in an athymic mouse was determined to be 4 to 6 days by longer-term studies. |
| Animal Model: | Female athymic mice (CD-1 nu/nu), human Colo-205 tumor xenograft model[2] |
| Dosage: | 62.5 μg or 250 μg per mouse |
| Administration: | Intraperitoneal injection, once |
| Result: | Inhibited the tumor growth. |
References
[1] Pavlicek A, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). Mol Cancer Ther. 2013 Dec;12(12):2929-39. DOI:10.1158/1535-7163.MCT-13-0442-T
[2] Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1;11(5):2063-73. DOI:10.1158/1078-0432.CCR-04-1070
[2] Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1;11(5):2063-73. DOI:10.1158/1078-0432.CCR-04-1070
Supplier
Wuhan Chemstan Biotechnology Co., Ltd.
Telephone027-65317797 15926423062
Websitehttp://www.chemstan.com/
Shanghai YuanYe Biotechnology Co., Ltd.
Telephone021-61312847; 18021002903
Websitehttp://www.shyuanye.com
ShangHai Biochempartner Co.,Ltd
Telephone177-54423994 17754423994
Websitehttps://www.biochempartner.com
Guangzhou Hongyuan Chemical Co.,Ltd
Telephone 15817493340
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1222417/0_EN.htm
Biolab Reagents
Telephone027-65279366 18108604356
Websitehttps://www.biolabreagent.com/
Wuhan Jingkangen Biomedical Technology Co., Ltd
Telephone13720134139 086-15871494362 13720134139
Websitehttps://www.jknbiochem.com
Shanghai Yifei Biotechnology Co. , Ltd.
Telephone021-65675885 18964387627
Websitehttp://www.efebio.com
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Telephone400-6206333 13167063860
Websitehttp://www.aladdin-e.com/
Changsha Fuzhen Biotechnology Co.，LTD
Telephone0731-13823398 15111215862
Websitehttps://www.chemicalbook.com/supplier/25777903/
Wanxin Biotechnology (Jiaxing) Co., LTD
Telephone0573-83568680 18057391398
Website
Atagenix Laboratories
Telephone027-87008169 17762441161
Websitehttps://www.abinscience.com/
AntibodySystem Laboratories SAS
Telephone 33175446423
Websitehttp://www.antibodysystem.com
Biosynth Biological Technology (Suzhou) Co Ltd
Telephone 51288865780
Websitehttp://www.biosynth.com
Cell Sciences
Telephone 9785721070
Websitehttp://www.cellsciences.com
Guangzhou Zhuanyan Biotechnology Co., Ltd.
Telephone18926165828
Websitegzzhuanyan.com
Shenzhen Campbell Biotechnology Co., Ltd.
Telephone18028747627
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1668922/0_EN.htm
Guangzhou Suyan Biotechnology Co., Ltd
Telephone18818417021
Websitehttps://www.gzsuyan.com/col.jsp?id=144
Guangzhou Chuangze Biotechnology Co., Ltd.
Telephone18312220236
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1638465/0_EN.htm
1of4
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine