Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC50 of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC50 in nanomolar level[1].
Definition
ChEBI: A natural product found in Isodon adenolomus.
References
[1] Yang Y, et al., Effects of three diterpenoids on tumour cell proliferation and telomerase activity. Nat Prod Res. 2009;23(11):1007-12. DOI:10.1080/14786410802295149
