934464-79-6

Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.

Kibdelone C is the major analogue of a potent antitumor complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention.

Kibdelone C is the major analogue of a potent antitumor complex.

Kibdelone C is the major analogue of a potent antitumour complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention.

Store at -20°C

[1] RANJALA RATNAYAKE. Kibdelones: Novel Anticancer Polyketides from a Rare Australian Actinomycete[J]. Chemistry - A European Journal, 2007, 13 5: 1610-1619. DOI: 10.1002/chem.200601236
[2] JANJIRA RUJIRAWANICH. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives[J]. Journal of the American Chemical Society, 2016, 138 33: 10561-10570. DOI: 10.1021/jacs.6b05484