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Histargin is an enzyme inhibitor isolated from Streptomyces roseoviridis.

Histargin is a carboxypeptidase B inhibitor with IC50 of 17 μg/ml and ＞ 100 μg/ml aganist Carboxypeptidase B and Carboxypeptidase A, respectively. Histargin can be produced by actinomycetes[1].

[1] Umezawa H, et al. Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes. J Antibiot (Tokyo). 1984 Sep;37(9):1088-90. DOI:10.7164/antibiotics.37.1088