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9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine [(S)-HPMPA] is a non-cyclic nucleotide analogue that acts as a potent and selective inhibitor of African swine fever virus (ASFV) replication. It has been reported that (S)-HPMPA exerts a specific, dose-dependent inhibitory effect on viral DNA synthesis. Furthermore, (S)-HPMPA also inhibits the production of late viral proteins (particularly IP-73) in ASFV-infected MS and Vero cells^[1].

9-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was prepared from 9-(S)-(2,3-dihydroxypropyl)adenine (DHPA) via its 3-O-chloromethanephosphonate^[2].

[1] O. Arzuza . (1988). Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine. Biochemical and Biophysical Research Communications, 154 1, Pages 27-32. https://doi.org/10.1016/0006-291X(88)90644-4
[2] A Holý, I R. (1987). Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA). Nucleic Acids Symposium Series, 18, 33–36.