Description
Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide; gamma-ketoaldehyde cpd; related to prostaglandin E2.
Definition
ChEBI:Levuglandin E2 is a levuglandin.
in vitro
Levuglandin E2 (LGE2), a rearrangement product derived from the prostaglandin endoperoxide, PGH2, causes repair-resistant DNA-protein cross-links and cell death (LD50 = 230 nM) in V79 Chinese hamster lung fibroblasts._x000D_
_x000D_
Reference: Biochemistry. 1993 Apr 20;32(15):4090-7. https://pubmed.ncbi.nlm.nih.gov/8471616/
in vivo
Treatment of LDL with LGE2 (Levuglandin E2) leads to uptake and degradation by mouse peritoneal macrophages. Oxidized LDL, but not acetyl LDL efficiently competed for binding and uptake of LGE2-modified 125I-LDL. This result suggests that LGE2-modified LDL was recognized by a class of scavenger receptor that demonstrated ligand specificity for oxidized LDL but not for acetyl LDL._x000D_
_x000D_
Reference: Biochim Biophys Acta. 1997 Jan 7;1344(1):1-5. https://pubmed.ncbi.nlm.nih.gov/9022751/
target
Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide.
