91432-48-3

Name	ascamycin
CAS	91432-48-3
MDL Number	MFCD09838109
MOL File	91432-48-3.mol

Synonyms

ascamycin 2-Chloro-5'-O-[(L-alanylamino)sulfonyl]adenosine 2-Chloro-5'-O-[[(S)-2-amino-1-oxopropyl]sulfamoyl]adenosine (+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine

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Hazard Information

Biological Activity

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. It has selective antibacterial activity against Xanthomonas bacteria, with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.

in vitro

The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface.

target

MIC: 0.4 μg/mL ( Xanthomonas citri ), 12.5 μg/mL ( Xanthomonas oryzae ) and 12.5 μg/mL ( Mycobacterium phlei )

Supplier

NewCan Biotech Limited

Telephone+86-0571-86912261 +8613735419629

Websitehttps://www.newcanbio.com/

Zhejiang Huida Biotech Co., LTD

Telephone0571-89903882 13626641628

Websitehttps://www.huidacollection.cn

Zhejiang Huida Biotech Co., LTD

Telephone0571-0571-89903882 15990081639

Websitehttps://www.huidacollection.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

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