91396-88-2

PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3.

NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

This stearoyl-CoA sesaturase 1 inhibitor, or SCD1 (FW = 213.24 g/mol; CAS 91396-88-2; Solubility: 43 mg/mL DMSO; <1 mg/mL H2O), also known as NSC 14613 an 4-pyridinecarboxylic acid, 2-phenylhydrazide, selectively eliminates human Pluripotent Stem Cells (hPSCs), while sparing a large array of progenitor and differentiated cells, thus providing a promising approach for minimizing the tumorigenic risk from residual undifferentiated cells. Closer examination identified PluriSIn #1 as an SCD1, thereby indicating a role for lipid metabolism in hPSC survival. PluriSIn #1 is likewise cytotoxic to mouse blastocysts, again suggesting a dependence on oleate in cells in a pluripotent state. SCD is key and highly regulated enzyme which catalyzes the D9-cis desaturation of a range of palmitoyl- and stearoyl-CoA to palmitoleoyl- and oleoyl-CoA respectively.

+4°C

1) Ben-David?et al. (2013),?Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell.?12?167 2) Zhang?et al. (2014),?Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle?13?762 3) Cheng?et al. (2014),?Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med.?3?1287