ChemicalBook CAS DataBase List 90880-35-6

90880-35-6

Name	NEUROPEPTIDE Y (HUMAN, RAT)
CAS	90880-35-6
Molecular Formula	C189H284N55O57RS
MDL Number	MFCD00081793
Molecular Weight	4270.68
MOL File	90880-35-6.mol

Chemical Properties

RTECS	QQ4064000
storage temp.	−20°C
solubility	H₂O: 1 mg/mL
form	powder
color	white
biological source	synthetic
Water Solubility	Soluble in water (1.5 mg/ml)
Sequence	Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
InChIKey	XKWCTHKJQNUFOQ-HRPSIEBRSA-N

Safety Data

WGK Germany	3
F	10-21
HS Code	2937190000
Storage Class	11 - Combustible Solids

Hazard Information

Description

Neuropeptide Y (NPY) is a peptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. Five subtypes of the NPY receptor have been identified. Subtypes Y₁ and Y₅ have known roles in the stimulation of feeding while Y₂ and Y₄ seem to have roles in satiety. NPY has also been shown to interact with the immune system, promoting gastrointestinal inflammation, as well as exhibiting an antimicrobial effect against several gut bacteria.

Uses

Neuropeptide Y (NPY) human has been used:

to study the effect of antiepileptic effects on pentylenetetrazole (PTZ) rats.
as a standard in high-performance liquid chromatography (HPLC) standard and control to verify specificity of the antibodies.
to study the effect of NPY on motor and electroencephalographic (EEG) seizures induced by kainic acid.

General Description

Neuropeptide Y is a regulatory molecule encoded by a gene mapped to human chromosome 7p15. Neuropeptide Y is a 36 amino acid protein with C-terminal α-amide structure. It is ubiquitously distributed in heart and brain, but at high levels in paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus, suprachiasmatic nucleus, median eminence, dorsomedial, hypothalamic nucleus, paraventricular thalamic nuclei. NPY is a member of antimicrobial peptide family, which also include dermaseptins, cecropins or magainins.

Biochem/physiol Actions

Vasoconstrictor; brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

storage

-20°C (desiccate)

References

[1] BALASUBRAMANIAM A. Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists[J]. Peptides, 1997, 18 3: Pages 445-457. DOI: 10.1016/s0196-9781(96)00347-6
[2] PETER HOLZER Aitak F Florian Reichmann. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis[J]. Neuropeptides, 2012, 46 6: Pages 261-274. DOI: 10.1016/j.npep.2012.08.005

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