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Ristocetin A is an antibiotic that was used to treat staphylococcal infections.¹ However, side effects of ristocetin A included thrombocytopenia and platelet agglutination. Ristocetin A is now used in two assays related to these actions, the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. Both assays are used in the diagnosis of von Willebrand disease and other bleeding disorders.^2,1

Ristocetin A is an antibiotic that is used to staphylococcal infections. However, side effects of ristocetin A included thrombocytopenia and platelet agglutination. Ristocetin A is now used in two assays related to these actions, the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. Both assays are used in the diagnosis of von Willebrand disease and other bleeding disorders.

1. Hawks, G.H. Antibiotic therapy of staphylococcal infection Can. Med. Assoc. J. 93(16),848-853(1965).
2. Castaman, G., Hillarp, A., and Goodeve, A. Laboratory aspects of von Willebrand disease: Test repertoire and options for activity assays and genetic analysis Haemophilia 20(suppl 4),65-70(2014).