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Pyrone-211 is a potent GPR84 agonist and AKR1C3 inhibitor. Pyrone-211 participates in an expanded polyamine pathway[1].

ChEBI: 4-hydroxy-6-heptylpyran-2-one is a 2-pyranone in which the hydrogens at positions 4 and 6 of 2H-pyran-2-one are replaced by hydroxy and heptyl groups respectively. It is a member of 2-pyranones and a heteroaryl hydroxy compound.

[1] Dudkina N, et al. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chem Biol. 2025 Jan 16;32(1):126-144.e18. DOI:10.1016/j.chembiol.2024.07.011