897671-69-1

28320-31-2

92-67-1

897671-69-1

The general procedure for the synthesis of N-([1,1'-biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-amine from 9,9-dimethyl-2-bromofluorene and 4-amino biphenyl was as follows: in a reactor 50.0 g (330 mmol) of 4-amino biphenyl, 43.2 g (276 mmol) of 2-bromo-9,9-dimethyl-9H-fluorene, 1.2 g (5.6 mmol) palladium acetate, 6.4 g (11.02 mmol) phosphine ligand, and 126 g (386 mmol) cesium carbonate were dissolved in 1000 mL of toluene. The reaction mixture was stirred under reflux conditions for 24 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by column chromatography afforded 57 g of the target product in 91% yield.