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GENERAL PROCEDURE: 1-methyl-3-amino-4-cyanopyrazole (0.03 mol) was dissolved in 7 mL of concentrated hydrochloric acid at 0°C and stirred at room temperature for 5 hours. After completion of the reaction, the mixture was poured into ice water and neutralized with 28% ammonia solution to pH 7. The precipitated white precipitate was washed with cold water and dried under vacuum.

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 5, p. 1751 - 1765
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 784 - 798
[3] Patent: WO2012/30924, 2012, A1. Location in patent: Page/Page column 134