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S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site III_Qo superoxide production (IC₅₀ = 1.7 μM) without altering normal bioenergetics function. It reduces production of H₂O₂ during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.

S3QEL 2 supresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation.

[1] ADAM L ORR. Suppressors of superoxide production from mitochondrial complex III[J]. Nature chemical biology, 2015, 11 11: 834-836. DOI: 10.1038/nchembio.1910