Bafilomycin B
1 is a fungal metabolite that has been found in
Streptomyces and has diverse biological activities.
1,2,3,4,5,6 It inhibits the activity of rat liver lysosomal vacuolar H
+-ATPase (V-ATPase) in a concentration-dependent manner.
4 Bafilomycin B
1 (10-1,000 nM) induces autophagosome accumulation in MCF-7 cells.
5 It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM.
3 Bafilomycin B
1 reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.
6 
