887647-69-0

YM-355179 is a novel, selective, and orally available antagonist for CC chemokine receptor 3.

YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively[1].

[1] A novel, selective, and orally available antagonist for CC chemokine receptor 3 DOI:10.1124/jpet.105.097048