88733-39-5

(3S)-3-(Methylamino)-4-(phenylamino)-1-butanol can be used to modify LiAlH4 with tridentate chiral ligands for the enantioselective reduction of alkylphenyl ketones 2 and α,β-unsaturated ketones.

β-benzyl N-benzyloxycarbonylaspartate4 is treated with ethyl chloroformate, Nmethymorpholine, and aniline. Subsequent reduction of the corresponding anilide with LiAlH4 gives the title  reagent in overall 80% yield.